Life Diagnostics生产ELISA试剂盒、SPARCL™试剂盒、用于临床前研究和兽医诊断的纯化生物标志物和抗体。Life Diagnostics的专业领域包括心血管、急性期、免疫毒性和免疫学生物标志物，涉及的物种包括老鼠、大鼠、兔子、猫、狗、猪、牛、猴子和鸡。此外，Life Diagnostics还开发了抗PEG单克隆抗体和ELISA试剂盒，用于检测PEG、mPEG化蛋白和抗PEG抗体。Life Diagnostics公司一直致力于为客户提供高质量的产品和优质的服务，赢得了广泛的赞誉和信任。
主要产品线
一、SPARCL™试剂盒
SPARCL™（空间近距分析试剂捕获发光）检测使用两种特定的抗体；一种与HRP结合，另一种与二氢化吖啶结合，一种化学发光底物。当HRP和二氢化吖啶结合的抗体与它们的靶生物标志物结合时，加入过氧化氢（触发溶液）后，HRP催化氧化邻近二氢化吖啶分子，导致与生物标志物浓度成比例的化学发光。远离HRP的二氢化吖啶分子不被氧化，因此不产生发光。这一原理可以开发一系列快速敏感的均相免疫分析方法。
典型的SPARCL™检测不需要洗涤步骤，只需一次孵育，从开始到结束大约需要45分钟。而ELISA需要1-4次孵育，1-3次洗涤步骤，需要2-4+小时。SPARCL™试剂盒需要一个能够同时加样和测量的光度计。Life Diagnostics提供一系列的SPARCL™检测试剂盒。
SPARCL™—ELISA的优秀替代品
–简单发光免疫测定
–单次培养30分钟
–无清洗步骤
–高灵敏度
–高吞吐量
参考文献
1. Baka R, et al. Quantitative proteomics of cerebrospinal fluid using tandem mass tags in dogs with recurrent epileptic sezures. J Proteomics 231:1039777 (2021)
2. Kules J, et al. The plasma proteome and the acute phase protein response in canine pyometra. J Proteomics 223:103817 (2020)
3. Liu M, et al. Cardiovascular-renal axis disorder and the acute-phase proteins in cats with congestive heart failure caused by primary cardiomyopathy. J Vet Intern Med. 34(3):1078-1090 (2020)
4. Dalanezi FM, et al. Concentrations of acute phase proteins in milk from cows with clinical mastitis caused by different pathogens. Pathogens 9(9):706 (2020)
5. Boulay I, et.al. SPARCL™: Use of a novel technology in validation of a Non-human primate and rat cardiac troponin-I assay in serum. CiToxLAB, 2016
6. Boulay I, et.al. SPARCL™: Use of a Novel Technology in Validation of a Non-Human Primate C-Reactive Protein Assay in Serum. CiToxLAB. 2016
部分产品信息
货号 | 产品名称 | 规格 |
AFP-SP-4 | Dog Alpha-fetoprotein | 96-well |
AGP-SP-11 | Cow AGP | 96-well |
AGP-SP-2 | Rat AGP | 96-well |
AGP-SP-5 | Chicken AGP | 96-well |
AGP-SP-8 | Cat AGP | 96-well |
CER-SP-4 | Dog Ceruloplasmin | 96-well |
CYSC-SP-2 | Rat Cystatin-C | 96-well |
HFABP-SP-20 | Human H-FABP | 96-well |
IGG1-SP-1 | Mouse IgG1 | 96-well |
IGG-SP-1 | Mouse IgG | 96-well |
MPEG-SP | mPEG | 96-well |
MYO-SP-1 | Mouse Myoglobin | 96-well |
MYO-SP-2 | Rat Myoglobin | 96-well |
MYO-SP-3 | Monkey Myoglobin | 96-well |
PEG-SP | PEG | 96-well |
TK1-SP-20 | Human Thymidine Kinase 1 | 96-well |
二、ELISA试剂盒
抗KLH、抗SRBC、抗破伤风毒素、抗DNP和抗TNP的IgM和IgG被用作免疫毒性的生物标志物。Life Diagnostics为小鼠、大鼠、鸡、猴子和人类生产这些生物标志物的ELISA试剂盒。
使用Life Diagnostics ELISA试剂盒发表的部分文献
1. Lo J, et al. Immature dendritic cell therapy confers durable immune modulation in an antigen-dependent and antigen-independent manner in nonobese diabetic mice. Journal of Immunology Research. Volume 2018 Article ID 5463879 (2108) [Mouse anti-KLH IgG & IgM]
2. Ksiazek A and Konarzewski M. Heat dissipation does not suppress an immune response in laboratory mice divergently selected for basal metabolic rate (BMR). Journal of Experimental Biology. 219:1542-1551 (2016) [Mouse anti-KLH IgG & IgM]
3. Tan X, et al. Immunotoxicological evaluation of genetically modified rice expressing Cry1Ab/AcProtein (TT51-1) by a 6-month feeding study on cynomolgus monkeys. PLoSONE 11(9):e0163879.doi:10.1371/journal.pone.0163879 (2016) [Monkey anti-KLH IgG & IgM]
4. Ma H, Wan S, and Xia C-Q. Immunosuppressive CD11b+Ly6Chi monocytes in pristane-induced lupus mouse model. Journal of Leukocyte Biology 99:1121 (2016). [Mouse anti-KLH IgG]
5. Nixon AE, et al. Fully human monoclonal antibody inhibitors of the neonatal Fc receptor reduce circulating IgG in non-human primates. Frontiers in Immunology. Volume 6, Article 176. (2015) [Monkey anti-tetanus toxoid & anti-KLH IgG & IgM]
6. Bernett MJ, et al. Immune suppression in cynomolgus monkeys by XPro9523. (2013) https://doi.org/10.4161/mabs.23976 [Monkey anti-KLH IgG & IgM]
7. Nain S and Smits JEG. Pathological, immunological and biochemical markers of subchronic arsenic toxicity in rats. Environmental Toxicology. (2010) http://onlinelibrary.wiley.com/doi/10.1002/tox.20635/abstract [Rat anti-KLH IgG & IgM]
8. Betz BC, Jordan-Williams KL, Wang C, Kang SG, Liao J, Logan MR, Kim CH and Taparowsky EJ. Batf coordinates multiple aspects of B and T cell function required for normal antibody responses. J. Exp. Med. 207(5):933-942 (2011) [Mouse anti-SRBC IgG & IgM] http://jem.rupress.org/content/207/5/933.full.pdf+html
9. Schaffer BS, Grayson MH and Wortham JM, et al. Immune competency of a hairless mouse strain for improved preclinical studies in genetically engineered mice. Mol. Cancer Ther. 9:2354-2364 (2010) [Mouse anti-KLH IgG & IgM] http://mct.aacrjournals.org/content/9/8/2354.full.pdf+html
10. Efanov A, Zanesi N, NazaryanN, Santanam U, Palmarchuck A Croce CM and Pekarsky Y. CD5+CD23+ leukemic cell populations in TCL1 transgenic mice show significantly increased proliferation and Akt phosphorylation. Leukemia 24:970-975 (2010) [Mouse anti-SRBC IgM]
部分产品信息
货号 | 产品名称 | 规格 |
KLHG-1 | Mouse Anti-KLH IgG ELISA | 96-well |
KLHM-1 | Mouse Anti-KLH IgM ELISA | 96-well |
KLHG-20 | Human Anti-KLH IgG ELISA | 96-well |
KLHM-20 | Human Anti-KLH IgM ELISA | 96-well |
TTG-2 | Rat Anti-Tetanus Toxoid IgG ELISA | 96-well |
TTM-2 | Rat Anti-Tetanus Toxoid IgM ELISA | 96-well |
DNPG-1 | Mouse Anti-DNP IgG ELISA | 96-well |
DNPM-1 | Mouse Anti-DNP IgM ELISA | 96-well |
TNPG-1 | Mouse Anti-TNP IgG ELISA | 96-well |
TNPM-1 | Mouse Anti-TNP IgM ELISA | 96-well |
SRBCG-5 | Chicken Anti-SRBC IgG ELISA | 96-well |
SRBCM-5 | Chicken Anti-SRBC IgM ELISA | 96-well |
三、蛋白
Life Diagnostics提供alpha-1-acid glycoprotein、CRP、haptoglobin、SAA等急性期生物标志物、troponin-I、myoglobin、FABP等心血管生物标志物、免疫球蛋白、Haptoglobin、Gc-Globulin肝脏生物标志物、Troponin-I骨骼肌生物标志物等系列产品，用于临床前研究研究和诊断分析开发。
部分产品信息
货号 | 产品名称 | 规格 |
8340 | Bovine (Cow) alpha-1-acid glycoprotein | 1 mg |
9060 | CAT LRG1 | 100 μg |
8160 | Cat Haptoglobin | 1 mg |
EXFABP-5-0.05 | Chicken EX-FABP | 0.05 mg |
9005 | Dog Serum Amyloid A (SAA) | 0.1 mg |
8356 | Rabbit a-1-Acid glycoprotein | 0.1 mg |
20110 | Mouse L-FABP | 0.1 mg |
20220 | Rat Gc-Globulin | 0.1 mg |
HAPT-2 | Rat Haptoglobin | 1 mg |
3610 | Chicken Skeletal Muscle Troponin-I | 0.1 mg |
3410 | Sheep Skeletal Muscle Troponin-I | 0.1 mg |
四、PEG相关产品
聚乙二醇（PEG）链连接到治疗性抗体和酶上，可以增加生物制剂的循环半衰期。Life Diagnostics生产单克隆抗体和ELISA试剂盒，用于检测PEG和甲氧基-PEG化蛋白。此外，Life Diagnostics还提供用于检测小鼠、大鼠和猴子体内抗PEG IgG和IgM的ELISA试剂盒。
部分产品信息
货号 | 产品名称 | 规格 |
5D6-3 | Anti-methoxy-PEG Monoclonal, Clone 5D6-3 | 100 μg |
1D9-6 | Anti-PEG Monoclonal, Clone 1D9-6 | 100 μg |
PEGPAB-01 | Anti-PEG Rabbit Polyclonal IgG Antibody | 100 μg |
PEGM-3 | Monkey Anti-PEG IgM ELISA | 96-well |
PEGM-20 | Human Anti-PEG IgM ELISA | 96-well |
PEGM-10 | Rabbit Anti-PEG IgM ELISA | 96-well |
PEGG-3 | Monkey Anti-PEG IgG ELISA | 96-well |
PEGG-20 | Human Anti-PEG IgG ELISA | 96-well |
PEGG-10 | Rabbit Anti-PEG IgG ELISA | 96-well |
PEGM-2 | Rat Anti-PEG IgM ELISA | 96-well |
PEGM-1 | Mouse Anti-PEG IgM ELISA | 96-well |
PBSA-00 | Multi PEGylated BSA | 1 mg |
PBSA-01P | Mono-PEGylated BSA (pentanoic acid-PEG, 20 kDa) | 100 μg |
五、抗体
Life Diagnostics提供alpha-1-acid glycoprotein等急性期生物标志物、troponin-I、myoglobin、FABP等心血管生物标志物、免疫球蛋白、Haptoglobin、Gc-Globulin肝脏生物标志物、Troponin-I骨骼肌生物标志物等蛋白抗体以及一系列二抗产品。
部分产品信息
货号 | 产品名称 | 规格 |
IGE-4-13H5 | Anti-Dog IgE Monoclonal | 1 mg |
IGE-4-4D1 | Anti-Dog IgE Monoclonal | 1 mg |
IGM-23-12B9 | Anti-Trout IgM Monoclonal | 1 mg |
IGM-23-2E7 | Anti-Trout IgM Monoclonal | 1 mg |
10C2-9 | Monoclonal Anti Monkey IgG | 1 mg |
6D11-2 | Monoclonal Anti Monkey IgG | 1 mg |
2C11-1-5 | Monoclonal Anti Monkey IgM | 1 mg |
7E8-1-13 | Monoclonal Anti Monkey IgM | 1 mg |
AGP-08-4F57 | Anti-cat alpha-1-acid glycoprotein | 1 mg |
下图为Life Diagnostics公司授权上海起发在中国区域的代理的授权书。
Life Diagnostics热卖产品
货号 | 产品名称 | 规格 | 品牌 |
CRP-3 | Monkey C-Reactive Protein (CRP) ELISA kit | 96 well | Life Diagnostics |
KLHM-3 | Monkey Anti-KLH IgM ELISA kit | 96 well | Life Diagnostics |
KLHG-3-INT | Monkey Anti-KLH IgG ELISA kit for export | 96 well | Life Diagnostics |
KLHM-2 | RAT ANTI-KLH IGM ELISA | 96 well | Life Diagnostics |
KLHG-2 | Rat Anti-KLH IgG ELISA | 96 well | Life Diagnostics |
1D9-6/MG | ANTI-PEG MONOCLONAL, CLONE 1D9-6 | 0.1mg | Life Diagnostics |
PEGG-20 | HUMAN ANTI-PEG IGG ELISA | 96 well | Life Diagnostics |
IGG-20 | Human IgG ELISA | 96 well | Life Diagnostics |
5H4-2-1mg | ANTI-METHOXY PEG | 1 mg | Life Diagnostics |
1D9-6-1mg | ANTI-PEG MONOCLONAL, CLONE | 1 mg | Life Diagnostics |
PBSA-00 | Multi PEGylated BSA - BSA with multiple covalently attached 20 kDa mPEG chains | 1 mg | Life Diagnostics |
PBAS-00-550-1mg | Multi PEGylated BSA | 1 mg | Life Diagnostics |
PBAS-00-550-10mg | Multi PEGylated BSA | 10 mg | Life Diagnostics |
5D6-3-0.1mg | ANTI-METHOXY PEG | 0.1 mg | Life Diagnostics |
KLHM-20 | HUMAN ANTI-KLH IGM ELISA | 96 well | Life Diagnostics |
5D6-3-1mg | ANTI-METHOXY PEG | 1 mg | Life Diagnostics |
5H4-2-0.1mg | ANTI-METHOXY PEG | 0.1 mg | Life Diagnostics |
KLHG-20 | Human Anti-KLH IgG ELISA | 96 well | Life Diagnostics |
CLUS-1 | Mouse Clusterin ELISA kit | 96 well | Life Diagnostics |
8511-0.1mg | Rat a-2-Macroglobulin | 0.1 mg | Life Diagnostics |
IGE-3 | MONKEY IGE ELISA | 96 well | Life Diagnostics |
IGE-2 | Rat IgE | 96 well | Life Diagnostics |
CTNI-3-US | MONKEY CARDIAC TROPONIN-I ELISA | 96 well | Life Diagnostics |
CTNI-1-US | Mouse cTnI, (serum/plasma) ELISA kit | 96 well | Life Diagnostics |
CTNI-1-HS | Mouse cTnI (serum) ELISA kit | 96 well | Life Diagnostics |
crp-sp-20 | HUMAN CRP SPARCL™ ASSAY | 96 well | Life Diagnostics |
CRP-2 | Rat C-Reactive Protein (CRP) ELISA kit | 96 well | Life Diagnostics |
8511-PT1MG | RAT ALPHA-2-MACROGLOBULIN, 8511 | 0.1 mg | Life Diagnostics |
作为Life Diagnostics在中国区域的总代理，上海起发将为中国客户提供全面的Life Diagnostics产品?；队蠹宜媸绷滴颐牵。?！
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